The impact of whole-genome sequencing on the reconstruction of human population history

  title={The impact of whole-genome sequencing on the reconstruction of human population history},
  author={Krishna R. Veeramah and Michael F. Hammer},
  journal={Nature Reviews Genetics},
Examining patterns of molecular genetic variation in both modern-day and ancient humans has proved to be a powerful approach to learn about our origins. Rapid advances in DNA sequencing technology have allowed us to characterize increasing amounts of genomic information. Although this clearly provides unprecedented power for inference, it also introduces more complexity into the way we use and interpret such data. Here, we review ongoing debates that have been influenced by improvements in our… 

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An inexpensive, reduced representation protocol for preparing resequencing targets is implemented, and the analytical tools necessary for making population genetic inferences are developed, applied to any species for which a draft or complete reference genome sequence is available.

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