The impact of whole genome sequencing on model system genetics: get ready for the ride.


Much of our understanding of how organisms develop and function is derived from the extraordinarily powerful, classic approach of screening for mutant organisms in which a specific biological process is disrupted. Reaping the fruits of such forward genetic screens in metazoan model systems like Drosophila, Caenorhabditis elegans, or zebrafish traditionally… (More)
DOI: 10.1534/genetics.109.112938


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