The impact of whole genome sequencing on model system genetics: get ready for the ride.

Abstract

Much of our understanding of how organisms develop and function is derived from the extraordinarily powerful, classic approach of screening for mutant organisms in which a specific biological process is disrupted. Reaping the fruits of such forward genetic screens in metazoan model systems like Drosophila, Caenorhabditis elegans, or zebrafish traditionally… (More)
DOI: 10.1534/genetics.109.112938

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