The impact of warfarin on the rate of progression of aortic stiffness in hemodialysis patients: a longitudinal study.

  title={The impact of warfarin on the rate of progression of aortic stiffness in hemodialysis patients: a longitudinal study.},
  author={Fabrice Mac-Way and Aur{\'e}lie Poulin and Mihai Silviu Utescu and Sacha A. De Serres and Karine Marquis and Pierre Douville and Simon Desmeules and Richard W. Lariviere and Marc Lebel and Mohsen Agharazii},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={29 11},
  • F. Mac-WayAurélie Poulin M. Agharazii
  • Published 1 November 2014
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
BACKGROUND Accelerated progression of aortic stiffness in patients with advanced chronic kidney disease is not well explained by the traditional cardiovascular risk factors. We hypothesized that vitamin K deficiency may result in an accelerated progression of aortic stiffness in the pro-calcifying uremic milieu. METHOD Eighteen hemodialysis (HD) patients on warfarin were matched to 54 HD patients without warfarin (control). Aortic stiffness was determined by carotid-femoral pulse wave… 

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