The impact of trisulfide modification of antibodies on the properties of antibody-drug conjugates manufactured using thiol chemistry.

Abstract

Antibody-drug conjugates (ADCs) are promising biotherapeutic agents for the treatment of cancer. The careful monitoring of critical quality attributes is important for ADCs' development, manufacturing and production. In this work, the effect of the presence of a trisulfide bond in the monoclonal antibody (mAb) conjugated to DM4 cytotoxic payload through a… (More)
DOI: 10.1080/19420862.2017.1285478

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Cite this paper

@article{Liu2017TheIO, title={The impact of trisulfide modification of antibodies on the properties of antibody-drug conjugates manufactured using thiol chemistry.}, author={Renpeng Liu and Xuan Chen and Junia Dushime and Megan Bogalhas and Alexandru C Lazar and Thomas Ryll and Lintao Wang}, journal={mAbs}, year={2017}, volume={9 3}, pages={490-497} }