The impact of treatment modality and radiation technique on outcomes and toxicity of patients with locally advanced oropharyngeal cancer

  title={The impact of treatment modality and radiation technique on outcomes and toxicity of patients with locally advanced oropharyngeal cancer},
  author={Abrahim A. Al-Mamgani and Peter H E Van rooij and Gerda M. Verduijn and Robert Mehilal and Jeroen D. F. Kerrebijn and Peter C. Levendag},
  journal={The Laryngoscope},
To investigate the impact of treatment modality and radiation technique on oncologic outcomes and toxicity of patients with locally advanced oropharyngeal cancer (OPC). 

Helical intensity‐modulated radiotherapy with concurrent chemotherapy for oropharyngeal squamous cell carcinoma: A prospective investigation of acute swallowing and toxicity patterns

The extent and timing of dysphagia and related toxicities during helical intensity‐modulated radiotherapy with chemotherapy for oropharyngeal squamous cell carcinoma is documented.

Development of a chemoradiation therapy toxicity staging system for oropharyngeal carcinoma

Develop an innovative tool to standardize representation of treatment toxicity and enable shared decision making by mapping provider‐based outcome descriptions to four overall stages of toxicity from

The impact of induction and/or concurrent chemoradiotherapy on acute and late patient‐reported symptoms in oropharyngeal cancer: Application of a mixed‐model analysis of a prospective observational cohort registry

The goal of this study was to comprehensively investigate the association of chemotherapy with trajectories of acute symptom development and late symptom recovery in patients with oropharyngeal

A systematic review of transoral robotic surgery and radiotherapy for early oropharynx cancer: A systematic review

To demonstrate the comparative effectiveness of transoral robotic surgery (TORS) to intensity modulated radiotherapy (IMRT) for early T‐stage oropharyngeal cancer.

Long‐term functional outcomes in surgically treated patients with oropharyngeal cancer

Long‐term functional outcomes in a cohort of surviving patients with oropharyngeal squamous cell carcinoma treated with primary surgery with Radiotherapy are reported.

Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy

This study assessed dysphagia, xerostomia, and neck fibrosis 3‐8 years after IMRT for head and neck cancer patients with HNCs undergoing intensity‐modulated radiotherapy.

Correlation between plan quality improvements and reduced acute dysphagia and xerostomia in the definitive treatment of oropharyngeal squamous cell carcinoma

To evaluate plan quality using volumetric‐modulated arc therapy (VMAT) and step‐and‐shoot intensity‐modulated radiation therapy (SS‐IMRT) techniques and for patients treated for oropharyngeal

Temporal course and predictive factors of analgesic opioid requirement for chemoradiation‐induced oral mucositis in oropharyngeal cancer

Oral mucositis (OM)‐related pain affects most patients with head and neck cancer during treatments, but its management is not standardized.

Effectiveness of honey on radiation‐induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta‐analysis and systematic review of literature

Honey has been shown to reduce radiation‐induced mucositis, which is a disabling effect of radiotherapy in head and neck cancers.

Efficacy and toxicity of docetaxel combination chemotherapy for advanced squamous cell cancer of the head and neck.

The aim of the present study was to evaluate the clinical effectiveness and toxicity of docetaxel with 5-fluorouracil and cisplatin as combination treatment in patients with curable or



Effect of Radiation Techniques in Treatment of Oropharynx Cancer

To compare the toxicity and outcomes of three radiotherapy techniques in the combined modality treatment of stage III–IV squamous cell carcinoma of the oropharynx, 3D‐RT, accelerated fractionation with concomitant boost, and intensity modulated radiotherapy (IMRT) are compared.

Value of intensity-modulated radiotherapy in Stage IV head-and-neck squamous cell carcinoma.

  • P. DirixS. Nuyts
  • Medicine
    International journal of radiation oncology, biology, physics
  • 2010

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients.

Origin of tumor recurrence after intensity modulated radiation therapy for oropharyngeal squamous cell carcinoma.

Are we influencing outcome in oropharynx cancer with intensity-modulated radiotherapy? An inter-era comparison.

Phase III study comparing cisplatin plus fluorouracil to paclitaxel, cisplatin, and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer.

Induction chemotherapy with PCF was better tolerated and resulted in a higher CR rate than CF, and new trials that compare induction chemotherapy plus CRT versus CRT alone are needed to better define the role of neoadjuvant treatment.