The impact of the glycoprotein Ia collagen receptor subunit A1648G gene polymorphism on coronary artery disease and acute myocardial infarction.

@article{Kroll2000TheIO,
  title={The impact of the glycoprotein Ia collagen receptor subunit A1648G gene polymorphism on coronary artery disease and acute myocardial infarction.},
  author={Hartmut Kroll and Andreas Gardemann and Anne Fechter and Werner G Haberbosch and Sentot Santoso},
  journal={Thrombosis and haemostasis},
  year={2000},
  volume={83 3},
  pages={392-6}
}
Platelet glycoprotein (GP) Ia is the major receptor for collagen and plays an important role in platelet adhesion and aggregation. Different gene polymorphisms have been identified that induce either various expression levels (C807T) or alterations of the tertiary structure (A1648G) of GPIa. Previously, we could demonstrate an association of the GPIa C807T dimorphism with nonfatal myocardial infarction. We have now analysed the influence of the GPIa A1648G (Br, HPA-5) dimorphism on the risk of… CONTINUE READING

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