The impact of the PAI-1 4G/5G polymorphism on the outcome of patients with ALI/ARDS.

  title={The impact of the PAI-1 4G/5G polymorphism on the outcome of patients with ALI/ARDS.},
  author={Iraklis Tsangaris and Argiris Tsantes and Stefanos Bonovas and Michalis Lignos and Petros Kopterides and Argiro Gialeraki and Evdoxia Rapti and Stylianos E. Orfanos and Ioanna Dimopoulou and Anthi Travlou and Apostolos Armaganidis},
  journal={Thrombosis research},
  volume={123 6},
INTRODUCTION Increased levels of plasminogen activator inhibitor-1 (PAI-1) have been associated with worse outcome in ALI/ARDS. A single guanosine insertion/deletion (4G/5G) polymorphism in the promoter region of the PAI-1 gene, may play an important role in the regulation of PAI-1 expression. The objective of the study was to evaluate the effect of this polymorphism on the outcome of critically ill patients with ALI/ARDS. MATERIALS AND METHODS 52 consecutive ventilated patients with ALI/ARDS… CONTINUE READING


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