The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects.

@article{Izadpanah2015TheIO,
  title={The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects.},
  author={Reza Izadpanah and Deborah J Sch{\"a}chtele and Andreas Pfn{\"u}r and Dong Lin and Douglas P. Slakey and Philip J. Kadowitz and Eckhard U. Alt},
  journal={American journal of physiology. Cell physiology},
  year={2015},
  volume={309 8},
  pages={
          C522-31
        }
}
Statins reduce atherosclerotic events and cardiovascular mortality. Their side effects include memory loss, myopathy, cataract formation, and increased risk of diabetes. As cardiovascular mortality relates to plaque instability, which depends on the integrity of the fibrous cap, we hypothesize that the inhibition of the potential of mesenchymal stem cells (MSCs) to differentiate into macrophages would help to explain the long known, but less understood "non-lipid-associated" or pleiotropic… Expand
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