The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects.

@article{Izadpanah2015TheIO,
  title={The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects.},
  author={Reza Izadpanah and Deborah J Sch{\"a}chtele and Andreas B Pfn{\"u}r and Dong Jun Lin and Douglas P. Slakey and Philip J. Kadowitz and Eckhard U. Alt},
  journal={American journal of physiology. Cell physiology},
  year={2015},
  volume={309 8},
  pages={
          C522-31
        }
}
Statins reduce atherosclerotic events and cardiovascular mortality. Their side effects include memory loss, myopathy, cataract formation, and increased risk of diabetes. As cardiovascular mortality relates to plaque instability, which depends on the integrity of the fibrous cap, we hypothesize that the inhibition of the potential of mesenchymal stem cells (MSCs) to differentiate into macrophages would help to explain the long known, but less understood "non-lipid-associated" or pleiotropic… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 56 REFERENCES

Two sides of the same coin: stem cells in cancer and regenerative medicine.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2014
VIEW 1 EXCERPT