The impact of retrotransposons on human genome evolution

  title={The impact of retrotransposons on human genome evolution},
  author={Richard Cordaux and Mark A. Batzer},
  journal={Nature Reviews Genetics},
Their ability to move within genomes gives transposable elements an intrinsic propensity to affect genome evolution. Non-long terminal repeat (LTR) retrotransposons — including LINE-1, Alu and SVA elements — have proliferated over the past 80 million years of primate evolution and now account for approximately one-third of the human genome. In this Review, we focus on this major class of elements and discuss the many ways that they affect the human genome: from generating insertion mutations… CONTINUE READING
Highly Influential
This paper has highly influenced 47 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 7 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
475 Citations
166 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 475 extracted citations


Publications referenced by this paper.
Showing 1-10 of 166 references

Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing

  • Li, B J.
  • Science 324,
  • 2009

Similar Papers

Loading similar papers…