The impact of retrotransposons on human genome evolution

@article{Cordaux2009TheIO,
  title={The impact of retrotransposons on human genome evolution},
  author={Richard Cordaux and Mark A. Batzer},
  journal={Nature Reviews Genetics},
  year={2009},
  volume={10},
  pages={691-703}
}
Their ability to move within genomes gives transposable elements an intrinsic propensity to affect genome evolution. Non-long terminal repeat (LTR) retrotransposons — including LINE-1, Alu and SVA elements — have proliferated over the past 80 million years of primate evolution and now account for approximately one-third of the human genome. In this Review, we focus on this major class of elements and discuss the many ways that they affect the human genome: from generating insertion mutations… CONTINUE READING
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