The impact of regular bisoprolol on the response to salbutamol in asthma: A double‐blind randomized placebo‐controlled crossover trial

  title={The impact of regular bisoprolol on the response to salbutamol in asthma: A double‐blind randomized placebo‐controlled crossover trial},
  author={Miriam R Bennett and Catherina L Chang and Christine M. Tuffery and Sandra J. Hopping and Robert J. Hancox},
  pages={225 - 232}
Non‐selective beta‐blockers impair the bronchodilator response to beta2‐agonists. Cardio‐selective beta1‐blockers are less likely to cause this effect, yet they remain relatively contraindicated in asthma. We investigated whether the response to salbutamol is impaired during cardio‐selective beta1‐blocker treatment in people with asthma. 
4 Citations
The safety of cardioselective β1-blockers in asthma: literature review and search of global pharmacovigilance safety reports
Observational data suggest that cardioselective β1-blocker use is not associated with increased asthma exacerbations, and the reluctance to use cardiosesophageal beta-blockers in people with asthma is not supported by this evidence.
Therapeutic Properties of Highly Selective β-blockers With or Without Additional Vasodilator Properties: Focus on Bisoprolol and Nebivolol in Patients With Cardiovascular Disease
Although head-to-head trials are largely lacking, there is no clear indication from published studies of an additional effect of nebivolol on clinical outcomes in patients with HFrEF or the magnitude of reductions of BP in Patients with hypertension.
Abdominal aortic aneurysm growth rates in patients undergoing local ultrasound surveillance
Abdominal aortic aneurysm ultrasound surveillance varies between hospitals in the United Kingdom. University Hospitals Bristol and Weston adopt a 6-monthly surveillance interval for 4.5–4.9 cm


Cardio‐selective and non‐selective beta‐blockers in chronic obstructive pulmonary disease: effects on bronchodilator response and exercise
There are limited data on the effects of beta‐blockers on the response to inhaled β2‐agonists and exercise capacity in patients with COPD, and this work is the first to evaluate the impact of these effects on patients with co‐existing cardiovascular disease.
Beta-blockers and asthma.
All drugs caused a fall in FEV1 but only atenolol did not differ significantly from placebo in this respect, and the bronchodilator response to inhaled isoprenaline was blocked by the 4 non-cardioselective drugs.
Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers.
Different classes of beta-blockers have different pulmonary effects, ie, effect on FEV(1), AHR, and response to additional beta(2)-agonists, as determined in a double-blind, placebo-controlled, randomized, cross-over study on patients with COPD.
Prescribing of β-adrenoceptor antagonists in asthma: an observational study
The results suggest that prescribing new oral β-blockers for the purpose of investigating potentially beneficial effects of chronic treatment would not lead to large increases in patients treated with oral steroids acutely in general practice.
Clinical Investigations: COPDDetrimental Effects of β-Blockers in COPD: A Concern for Nonselective β-Blockers
Different classes of β-blockers have different pulmonary effects, and only propranolol reduced FEV 1 and the bronchodilating effect of formoterol reduced AHR and response to additional β 2 -agonists did not occur by celiprolol.
β‐Blocker Therapy in Veterans with Asthma or Chronic Obstructive Pulmonary Disease
Study Objectives. To determine whether an association exists between health care resource use and β‐blocker therapy in patients with asthma or chronic obstructive pulmonary disease (COPD), and to
Bronchodilator tolerance: the impact of increasing bronchoconstriction
Regular salbutamol resulted in attenuation of the acute response to β‐agonist, which was increasingly evident with greater bronchoconstriction, which conferred greater susceptibility to the effects of bronchodilator tolerance.
Tolerance to beta-agonists during acute bronchoconstriction.
Investigating whether bronchodilator tolerance can be demonstrated during acute bronchoconstriction finds that continuous treatment with inhaled beta-agonists may lead to a reduced response to emergency beta-agonist treatment during asthma exacerbations.
A comparison of four beta-adrenoceptor antagonists in patients with asthma.
The bronchodilator response to inhaled isoprenaline was blocked by propranolol and pindolol but not by acebutolol and atenolol, and partial agonist activity did not appear to be clinically useful.
Effects of beta-adrenoceptors blocking eye drops in patients with chronic bronchitis.
It appeared that only heart rate lowers significantly under the influence of the beta-blocker eyedrop, the other parameters did not change and no difference was noticed between the three eyedrops, however, comparison of individual values showed a significant decrease of forced expiratory volume in one second in certain subjects and this, although betaxolol is a beta 1 selective beta-blocks.