The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives.

@article{Simons2016TheIO,
  title={The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives.},
  author={Yuval B Simons and Guy Sella},
  journal={Current opinion in genetics & development},
  year={2016},
  volume={41},
  pages={150-158}
}
Over the past decade, there has been both great interest and confusion about whether recent demographic events-notably the Out-of-Africa-bottleneck and recent population growth-have led to differences in mutation load among human populations. The confusion can be traced to the use of different summary statistics to measure load, which lead to apparently conflicting results. We argue, however, that when statistics more directly related to load are used, the results of different studies and data… CONTINUE READING
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