The impact of ranitidine on monocyte responses in the context of solid tumors

@inproceedings{VilaLeahey2016TheIO,
  title={The impact of ranitidine on monocyte responses in the context of solid tumors},
  author={Ava Vila-Leahey and Dakota Rogers and Jean S Marshall},
  booktitle={Oncotarget},
  year={2016}
}
Monocytes and myeloid derived suppressor cells (MDSC) have been implicated on the regulation of tumor growth. Histamine is also important for regulating MDSC responses. Oral administration of the H2 receptor antagonist ranitidine can inhibit breast tumor growth and metastasis. In the current study, we examined the impact of oral ranitidine treatment, at a clinically relevant dose, on multiple murine tumor models. The impact of ranitidine on monocyte responses and the role of CCR2 in ranitidine… CONTINUE READING
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