The impact of pulmonary diseases on the fate of inhaled medicines--a review.

@article{Wang2014TheIO,
  title={The impact of pulmonary diseases on the fate of inhaled medicines--a review.},
  author={Yi-bo Wang and Alan B. Watts and Jay I. Peters and Robert O Williams},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={461 1-2},
  pages={112-28}
}
The portfolio of compounds approved for inhalation therapy has expanded rapidly for treatment of lung diseases. To assess the efficacy and safety of inhaled medicines, a better understanding of their fate in the lungs is essential; especially in diseased lungs where changes in anatomical structure, ventilation parameters and breathing pattern may occur. In this article, the impact of lung pathophysiology factors on the fate of inhaled medicines is reviewed, and discussed in the context of… CONTINUE READING