The impact of prophylactic fresh-frozen plasma and cryoprecipitate on the incidence of central nervous system thrombosis and hemorrhage in children with acute lymphoblastic leukemia receiving asparaginase.

@article{Abbott2009TheIO,
  title={The impact of prophylactic fresh-frozen plasma and cryoprecipitate on the incidence of central nervous system thrombosis and hemorrhage in children with acute lymphoblastic leukemia receiving asparaginase.},
  author={Lesleigh S Abbott and Mariana Deevska and Conrad Vincent Fernandez and David Dix and Victoria E. Price and Hao Wang and L. Neergaard Parker and Margaret Yhap and Colleen Fitzgerald and Dorothy R Barnard and Jason N Berman},
  journal={Blood},
  year={2009},
  volume={114 25},
  pages={5146-51}
}
Asparaginase (ASP) therapy is associated with depletion of antithrombin (AT) and fibrinogen (FG). Potential toxicities include central nervous system thrombosis (CNST) and hemorrhage. Historical practice at the Izaak Walton Killam Health Centre (IWK) involves measuring AT and FG levels after ASP administration and transfusing fresh-frozen plasma (FFP) or cryoprecipitate (CRY) to prevent thrombotic and hemorrhagic complications. To determine whether this reduced these complications in children… CONTINUE READING

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