The impact of proband mediated information dissemination in families with a BRCA1/2 gene mutation.

@article{Sermijn2004TheIO,
  title={The impact of proband mediated information dissemination in families with a BRCA1/2 gene mutation.},
  author={Erica Sermijn and Guido Goelen and Erik Teugels and Louise Kaufman and Maryse Bonduelle and Bart Neyns and Bruce Poppe and Anne De Paepe and Jacques L P De Gr{\`e}ve},
  journal={Journal of medical genetics},
  year={2004},
  volume={41 3},
  pages={e23}
}
S ince the identification of the BRCA1 (17q21) and BRCA2 (13q12–13) genes as the major predisposition genes for hereditary breast and ovarian cancer (HBOC), genetic counselling and predictive testing has progressively been introduced and applied throughout the world. In many centres, the initial approach towards these families has been very cautious, mainly because of lack of prospective data on the effects of preventive measures to be proposed for mutation carriers and the uncertainty of the… CONTINUE READING

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