The impact of prenatal exposure to air pollution on childhood wheezing and asthma: A systematic review

@article{Hehua2017TheIO,
  title={The impact of prenatal exposure to air pollution on childhood wheezing and asthma: A systematic review},
  author={Zhang Hehua and Chang Qing and Gao Shanyan and Wu Qijun and Zhao Yuhong},
  journal={Environmental Research},
  year={2017},
  volume={159},
  pages={519–530}
}

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References

SHOWING 1-10 OF 54 REFERENCES
Effect of outdoor air pollution on asthma exacerbations in children and adults: Systematic review and multilevel meta-analysis
TLDR
This meta-analysis provides evidence of the association between selected air pollutants and asthma exacerbations for different lags, and in children, the association was significant for NO2, SO2 and PM2.5.
Air pollution exposure during pregnancy and infancy and childhood asthma
TLDR
There is no evidence suggesting that the vehicle exhaust level at home during gestation or infancy, using NO x as a proxy, is associated with the risk of childhood asthma, but there is a tendency that moving to a residence with higher concentrations than the first was associated with an increased risk for asthma.
Prenatal exposures and the development of childhood wheezing illnesses
TLDR
Several common potentially modifiable prenatal exposures appear to be consistently associated with childhood wheezing illnesses (e.g. parental smoking, outdoor air pollution, and maternal stress), however, the effect of many other prenatal exposures on the onset of childhood wheazing illnesses remains unclear.
The health burden of pollution: the impact of prenatal exposure to air pollutants
  • S. Vieira
  • Medicine
    International journal of chronic obstructive pulmonary disease
  • 2015
TLDR
Primary scientific evidence of the effects of air pollution during pregnancy and the impact of these effects on the fetus, infant health, and in particular, the respiratory system is analyzed.
Effect of Early Life Exposure to Air Pollution on Development of Childhood Asthma
TLDR
A statistically significantly increased risk of asthma diagnosis with increased early life exposure to CO, NO, NO2, PM10, SO2, and black carbon is observed and the hypothesis that early childhood exposure to air pollutants plays a role in development of asthma is supported.
Prenatal Particulate Air Pollution and Asthma Onset in Urban Children. Identifying Sensitive Windows and Sex Differences.
TLDR
Higher prenatal PM2.5 exposure at midgestation was associated with asthma development by age 6 years in boys, and distributed lag models adjusting for child age, sex, and maternal factors showed that increased exposure levels at 16-25 weeks gestation were significantly associated with early childhood asthma development.
Separate and joint effects of tranplacental and postnatal inhalatory exposure to polycyclic aromatic hydrocarbons: Prospective birth cohort study on wheezing events
TLDR
It appears that prenatal PAH exposure may precipitate and intensify early onset of wheezing symptoms in childhood, resulting from the postnatal exposure and suggest that success in reducing the incidence of respiratory diseases in children would depend on reducing both fetal and childhood exposure to air pollution.
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