The impact of pregnane X receptor activation on liver fibrosis.

@article{Wright2006TheIO,
  title={The impact of pregnane X receptor activation on liver fibrosis.},
  author={Matthew C. Wright},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 6},
  pages={
          1119-23
        }
}
  • M. Wright
  • Published 1 December 2006
  • Biology, Medicine
  • Biochemical Society transactions
The PXR (pregnane X receptor) is a nuclear receptor transcription factor that is activated by a range of endobiotics and xenobiotics. The activated PXR modulates the transcription of genes in hepatocytes (the main functional cell of the liver) associated with endobiotic and xenobiotic uptake, metabolism and excretion. However, activation of the PXR also inhibits a deleterious response of the liver to chronic damage--that of fibrosis. The antifibrogenic mode of action is mediated through changes… 
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PXR has a multiplicity of roles in vivo and is being revealed as behaving like a “Jekyll and Hyde” nuclear hormone receptor, and the need for discovery of antagonists of PXR to further probe its biology and therapeutic applications is elucidated.
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References

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TLDR
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