The impact of population expansion and mutation rate heterogeneity on DNA sequence polymorphism.

@article{ArisBrosou1996TheIO,
  title={The impact of population expansion and mutation rate heterogeneity on DNA sequence polymorphism.},
  author={St{\'e}phane Aris-Brosou and Laurent Excoffier},
  journal={Molecular biology and evolution},
  year={1996},
  volume={13 3},
  pages={494-504}
}
In order to study the effect of mutation rate heterogeneity on patterns of DNA polymorphism, we simulated samples of DNA sequences with gamma-distributed nucleotide substitution rates in stationary and expanding populations. We find that recent population expansions and mutation rate heterogeneity have similar effects on several polymorphism indicators, like the shape and the mean of the observed pairwise difference distribution, or the number of segregating sites. The inferred size of… CONTINUE READING
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