The impact of polymorphisms in chemokine and chemokine receptors on outcomes in liver transplantation.

@article{Schrppel2002TheIO,
  title={The impact of polymorphisms in chemokine and chemokine receptors on outcomes in liver transplantation.},
  author={Bernd Schr{\"o}ppel and Michael Fischereder and Rami Ashkar and Marvin Lin and Bernhard Kraemer and Brad Mardera and T. B. Schiano and Barbara R. Murphy},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2002},
  volume={2 7},
  pages={
          640-5
        }
}
Chemokines and their corresponding receptors likely play a central role in directing mononuclear cells to the graft sites during rejection. Genes for the chemokine stromal derived factor-1 (SDF1) and CC chemokine receptors CCR2 and CCR5 are characterized by polymorphisms which alter their function. We genotyped DNA of 207 liver transplant recipients by PCR or PCR-RFLP for CCR2-641, CCR5delta32, and SDF1-3'A polymorphisms, and examined their association on outcomes in liver allograft recipients… CONTINUE READING
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