The impact of nucleic acid secondary structure on PNA hybridization.

  title={The impact of nucleic acid secondary structure on PNA hybridization.},
  author={Bruce A Armitage},
  journal={Drug discovery today},
  volume={8 5},
Hybridization of oligonucleotides and their analogues to complementary DNA or RNA sequences is complicated by the presence of secondary and tertiary structure in the target. In particular, folding of the target nucleic acid imposes substantial thermodynamic penalties to hybridization. Slower kinetics for hybridization can also be observed, relative to an unstructured target. The development of high affinity oligonucleotide analogues such as peptide nucleic acid (PNA) can compensate for the… CONTINUE READING

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