The impact of nephrectomy and renal transplantation on serum levels of soluble Klotho protein.

@article{Akimoto2013TheIO,
  title={The impact of nephrectomy and renal transplantation on serum levels of soluble Klotho protein.},
  author={Tetsu Akimoto and Takaaki Kimura and Yuko Watanabe and Nobuo Ishikawa and Yoshitaka Iwazu and Osamu Saito and Shigeaki Muto and Takashi Yagisawa and Eiji Kusano},
  journal={Transplantation proceedings},
  year={2013},
  volume={45 1},
  pages={134-6}
}
BACKGROUND Klotho, a single-pass transmembrane protein primarily expressed in the kidneys, parathyroid glands, and choroid plexus of the brain, has a short cytoplasmic tail and a long extracellular domain, which can be cleaved and released as a soluble form. However, information regarding the origins and kinetics of soluble serum Klotho remains poorly understood. We evaluated serial changes in serum Klotho levels among living donors before and after retroperitoneoscopic nephrectomy as well as… CONTINUE READING

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