The impact of natural selection on an ABCC11 SNP determining earwax type.

@article{Ohashi2011TheIO,
  title={The impact of natural selection on an ABCC11 SNP determining earwax type.},
  author={Jun Ohashi and Izumi Naka and Naoyuki Tsuchiya},
  journal={Molecular biology and evolution},
  year={2011},
  volume={28 1},
  pages={
          849-57
        }
}
A nonsynonymous single nucleotide polymorphism (SNP), rs17822931-G/A (538G>A; Gly180Arg), in the ABCC11 gene determines human earwax type (i.e., wet or dry) and is one of most differentiated nonsynonymous SNPs between East Asian and African populations. A recent genome-wide scan for positive selection revealed that a genomic region spanning ABCC11, LONP2, and SIAH1 genes has been subjected to a selective sweep in East Asians. Considering the potential functional significance as well as the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 28 REFERENCES

DNA polymorphisms–an update

H Rajeevan, MV Osier, KH Cheung
  • Nucleic Acids Res
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2009
VIEW 2 EXCERPTS