The impact of measurement error on the comparison of two treatments using a responder analysis.

@article{Oppenheimer1999TheIO,
  title={The impact of measurement error on the comparison of two treatments using a responder analysis.},
  author={Lawrence Oppenheimer and Uma A Kher},
  journal={Statistics in medicine},
  year={1999},
  volume={18 16},
  pages={2177-88}
}
Investigators often report results of studies comparing the proportions of subjects who have clinically meaningful responses to various therapeutic regimens. When the outcome variable is a continuous measure this involves dichotomizing the observed response based on a predefined threshold value. The effect of this strategy is examined, paying particular attention to the impact of measurement error on the resulting estimates of treatment effect (difference in the proportion responding… CONTINUE READING