The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies.

@article{Fussenegger2001TheIO,
  title={The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies.},
  author={Martin Fussenegger},
  journal={Biotechnology progress},
  year={2001},
  volume={17 1},
  pages={1-51}
}
Regulation of heterologous gene expression is of prime importance for a wide variety of basic and applied biological research areas including functional genomics, tissue engineering, gene therapy, and biopharmaceutical manufacturing. Initial gene regulation strategies employed endogenous responsive elements, which resulted in pleiotropic interference of transgene expression with host regulatory networks. Current regulation systems are binary and consist of chimeric transactivators and… CONTINUE READING
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