The impact of long-term in vitro expansion on the senescence-associated markers of human adipose-derived stem cells.

@article{Safwani2012TheIO,
  title={The impact of long-term in vitro expansion on the senescence-associated markers of human adipose-derived stem cells.},
  author={Wan Kamarul Zaman Wan Safwani and Suzana Makpol and Somasundaram Sathapan and Kien Hui Chua},
  journal={Applied biochemistry and biotechnology},
  year={2012},
  volume={166 8},
  pages={2101-13}
}
Human adipose-derived stem cells (ASCs) have generated a great deal of excitement in regenerative medicine. However, their safety and efficacy issue remain a major concern especially after long-term in vitro expansion. The aim of this study was to investigate the fundamental changes of ASCs in long-term culture by studying the morphological feature, growth kinetic, surface marker expressions, expression level of the senescence-associated genes, cell cycle distribution and ß-galactosidase… CONTINUE READING

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Biotechnol

  • W. K. Z. Wan Safwani, S. Makpol, S. Sathapan, K. H. Chua
  • 2011

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