The impact of interleukin 12B (1188A>C), interleukin 16 (-295T>C), and interleukin 18 (607C>A, 137G>C) gene polymorphisms on long-term renal transplant function and recipient outcomes.

@article{Pawlus2014TheIO,
  title={The impact of interleukin 12B (1188A>C), interleukin 16 (-295T>C), and interleukin 18 (607C>A, 137G>C) gene polymorphisms on long-term renal transplant function and recipient outcomes.},
  author={Jolanta Pawlus and Anita Sierocka and Karol Tejchman and Zbigniew Ziętek and Maciej Romanowski and Andrzej Pawlik and Jerzy Sieńko and Maciej Żukowski and Kazimierz Ciechanowski and Marek Ostrowski and Tadeusz Sulikowski},
  journal={Transplantation proceedings},
  year={2014},
  volume={46 6},
  pages={2079-82}
}
BACKGROUND Inflammatory mediators play an important role in kidney graft outcome. The cytokine and chemokine gene polymorphisms are associated with variable production, activity, expression, or ligand-receptor affinity. Genetic variation in the DNA sequence of the interleukin 12B (IL12B), interleukin 16 (IL16), and interleukin 18 (IL18) genes may lead to altered cytokine production and activity. These variations can lead to changes in individual patient outcomes after kidney transplantation. It… CONTINUE READING