The impact of interferon-alpha2 on HLA genes in patients with polycythemia vera and related neoplasms.

Abstract

Gene expression profiling in Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) have unraveled significant deregulation of several immune and inflammation genes of potential importance for clonal evolution. Other mechanisms might be downregulation of major histocompatibility class I and II genes used by tumor cells to escape antitumor T-cell-mediated immune responses. Several genes encoding human leukocyte antigen (HLA) class I and II molecules have been shown to be significantly downregulated. Upregulation of HLA genes is considered one of the mechanisms of action of interferon (IFN)-alpha2, but regulation of these genes during IFN-alpha2 treatment in MPNs has never been studied. Our findings show a significant upregulation of several HLA genes of importance for tumor immune surveillance by IFN-alpha2 treatment in MPNs. This mechanism might enhance the cytotoxic potential of immune cells against MPNs and explain the induction of minimal residual disease by IFN-alpha2 treatment in these patients.

DOI: 10.1080/10428194.2016.1262032

Cite this paper

@article{Skov2017TheIO, title={The impact of interferon-alpha2 on HLA genes in patients with polycythemia vera and related neoplasms.}, author={Vibe Skov and Caroline Hasselbalch Riley and Mads Thomassen and Lasse Kj{\ae}r and Thomas Stauffer Larsen and Ole Weis Bjerrum and Torben Arvid Kruse and Hans Carl Hasselbalch}, journal={Leukemia & lymphoma}, year={2017}, volume={58 8}, pages={1914-1921} }