The impact of insulin resistance on the kidney and vasculature

@article{Artunc2016TheIO,
  title={The impact of insulin resistance on the kidney and vasculature},
  author={Ferruh Artunc and Erwin D. Schleicher and Cora Weigert and Andreas Fritsche and Norbert Stefan and Hans-Ulrich H{\"a}ring},
  journal={Nature Reviews Nephrology},
  year={2016},
  volume={12},
  pages={721-737}
}
Insulin resistance is a systemic disorder that affects many organs and insulin-regulated pathways. The disorder is characterized by a reduced action of insulin despite increased insulin concentrations (hyperinsulinaemia). The effects of insulin on the kidney and vasculature differ in part from the effects on classical insulin target organs. Insulin causes vasodilation by enhancing endothelial nitric oxide production through activation of the phosphatidylinositol 3-kinase pathway. In insulin… CONTINUE READING
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