The impact of high density receptor clusters on VEGF signaling

  title={The impact of high density receptor clusters on VEGF signaling},
  author={Ye Chen and C. Short and {\'A}. Hal{\'a}sz and J. Edwards},
  journal={Electronic proceedings in theoretical computer science},
  • Ye Chen, C. Short, +1 author J. Edwards
  • Published 2013
  • Chemistry, Computer Science, Medicine, Biology, Mathematics
  • Electronic proceedings in theoretical computer science
Vascular endothelial growth factor (VEGF) signaling is involved in the process of blood vessel development and maintenance. Signaling is initiated by binding of the bivalent VEGF ligand to the membrane-bound receptors (VEGFR), which in turn stimulates receptor dimerization. Herein, we discuss experimental evidence that VEGF receptors localize in caveloae and other regions of the plasma membrane, and for other receptors, it has been shown that receptor clustering has an impact on dimerization… Expand
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