The impact of high density receptor clusters on VEGF signaling

  title={The impact of high density receptor clusters on VEGF signaling},
  author={Ye Chen and Christopher Short and {\'A}d{\'a}m M. Hal{\'a}sz and Jeremy S. Edwards},
  journal={Electronic proceedings in theoretical computer science},
Vascular endothelial growth factor (VEGF) signaling is involved in the process of blood vessel development and maintenance. Signaling is initiated by binding of the bivalent VEGF ligand to the membrane-bound receptors (VEGFR), which in turn stimulates receptor dimerization. Herein, we discuss experimental evidence that VEGF receptors localize in caveloae and other regions of the plasma membrane, and for other receptors, it has been shown that receptor clustering has an impact on dimerization… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 31 references

Rapid phosphoturnover by receptor tyrosine kinases impacts downstream signaling and drug binding

  • L. B. Kleiman, T. Maiwald, H. Conzelman, D. A. Lauffenburger, P. K. Sorger
  • Molecular Cell 43, p. 723C737,
  • 2011
1 Excerpt

Signaling by Receptor Tyrosine Kinases

  • J. R. Pfeiffer, Z. Surviladze, B. S. Wilson, M. M. Davis
  • Cell
  • 2010

Spatiotemporal modeling of signalingprotein recruitment to EGFR

  • Y. Umemura, K. Suzuki, R. Iino, H. Murakoshi
  • BMC Systems Biology
  • 2010

Structure and Function of VEGF Receptors

  • K. E. Stuttfield
  • Ballmer-Hofer
  • 2009
1 Excerpt

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