The impact of genomic alterations on the transcriptome: a prostate cancer cell line case study

@article{Chaudhary2006TheIO,
  title={The impact of genomic alterations on the transcriptome: a prostate cancer cell line case study},
  author={Jaideep Chaudhary and Marcin Schmidt},
  journal={Chromosome Research},
  year={2006},
  volume={14},
  pages={567-586}
}
Genetic instability may lead to the loss/gain of transcriptional control. Here we investigated the effect of genomic instability, that is loss/gain of chromosomal regions on the global transcriptome of prostate cancer cell line DU145. The genomic loss/gain map obtained through BAC array-based CGH was superimposed on the dynamic transcriptome of DU145 cells treated with serum for 0 h (serum starved), 2 h and 12 h. The genomic analysis suggested that in DU145 cells: (1) chromosomal gains are… CONTINUE READING