The impact of genetic polymorphisms and patient characteristics on warfarin dose requirements: a cross-sectional study in Iran.

@article{Namazi2010TheIO,
  title={The impact of genetic polymorphisms and patient characteristics on warfarin dose requirements: a cross-sectional study in Iran.},
  author={Soha Namazi and Negar Azarpira and Fatemeh Hendijani and Maryam Banan Khorshid and Ghazal Vessal and Ahmad R. Mehdipour},
  journal={Clinical therapeutics},
  year={2010},
  volume={32 6},
  pages={
          1050-60
        }
}
BACKGROUND Warfarin is the most commonly prescribed oral anticoagulant drug for prophylaxis and treatment of venous and arterial thromboembolic disorders. Its anticoagulant effect is widely variable between patients because of pharmacodynamic, pharmacokinetic, and pharmacogenetic factors. OBJECTIVE This study was conducted to identify the associations between demographic characteristics, warfarin maintenance dose, and genetic polymorphisms of cytochrome P450 (CYP) 2C19, CYP2C9, and vitamin K… CONTINUE READING
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