The impact of extremophiles on structural genomics (and vice versa)

  title={The impact of extremophiles on structural genomics (and vice versa)},
  author={F. E. Jenney and M. Adams},
  • F. E. Jenney Jr, M. Adams
  • Published 2007
  • Medicine, Biology
  • Extremophiles
  • The advent of the complete genome sequences of various organisms in the mid-1990s raised the issue of how one could determine the function of hypothetical proteins. While insight might be obtained from a 3D structure, the chances of being able to predict such a structure is limited for the deduced amino acid sequence of any uncharacterized gene. A template for modeling is required, but there was only a low probability of finding a protein closely-related in sequence with an available structure… CONTINUE READING
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