The impact of extremophiles on structural genomics (and vice versa)
@article{JenneyJr2007TheIO, title={The impact of extremophiles on structural genomics (and vice versa)}, author={Francis E. Jenney Jr and Michael W. W. Adams}, journal={Extremophiles}, year={2007}, volume={12}, pages={39-50} }
The advent of the complete genome sequences of various organisms in the mid-1990s raised the issue of how one could determine the function of hypothetical proteins. While insight might be obtained from a 3D structure, the chances of being able to predict such a structure is limited for the deduced amino acid sequence of any uncharacterized gene. A template for modeling is required, but there was only a low probability of finding a protein closely-related in sequence with an available structure…
49 Citations
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