The impact of extremophiles on structural genomics (and vice versa)

@article{JenneyJr2007TheIO,
  title={The impact of extremophiles on structural genomics (and vice versa)},
  author={Francis E. Jenney Jr and Michael W. W. Adams},
  journal={Extremophiles},
  year={2007},
  volume={12},
  pages={39-50}
}
The advent of the complete genome sequences of various organisms in the mid-1990s raised the issue of how one could determine the function of hypothetical proteins. While insight might be obtained from a 3D structure, the chances of being able to predict such a structure is limited for the deduced amino acid sequence of any uncharacterized gene. A template for modeling is required, but there was only a low probability of finding a protein closely-related in sequence with an available structure… 
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