The impact of erythropoietin on short-term changes in phosphorylation of brain protein kinases in a rat model of traumatic brain injury.

@article{Valable2010TheIO,
  title={The impact of erythropoietin on short-term changes in phosphorylation of brain protein kinases in a rat model of traumatic brain injury.},
  author={Samuel Valable and Gilles Francony and Pierre Bouzat and M Fevre and Nouara Mahious and Valentine Bouet and R{\'e}gine Farion and Emmanuel Luc Barbier and Hana Lahrech and Chantal R{\'e}my and Edwige Petit and Christoph Segebarth and Myriam Bernaudin and Jean-François Payen},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2010},
  volume={30 2},
  pages={361-9}
}
We found that recombinant human erythropoietin (rhEPO) reduced significantly the development of brain edema in a rat model of diffuse traumatic brain injury (TBI) (impact-acceleration model). In this study, we investigated the molecular and intracellular changes potentially involved in these immediate effects. Brain tissue nitric oxide (NO) synthesis, phosphorylation level of two protein kinases (extracellular-regulated kinase (ERK)-1/-2 and Akt), and brain water content were measured 1 (H1… CONTINUE READING
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