The impact of early adverse care on HPA axis development: Nonhuman primate models

  title={The impact of early adverse care on HPA axis development: Nonhuman primate models},
  author={Mar M. Sanchez},
  journal={Hormones and Behavior},
  • M. Sanchez
  • Published 1 November 2006
  • Psychology, Biology
  • Hormones and Behavior
The Neurobiology of Intervention and Prevention in Early Adversity.
The research on three neurobiological systems relevant to interventions for populations experiencing high levels of early adversity are summarized: the hypothalamic-adrenal-pituitary axis, the prefrontal cortex regions involved in executive functioning, and the system involved in threat detection and response, particularly the amygdala.
Nonhuman primate models of depression: effects of early experience and stress.
The NHP offers an excellent model to research mechanisms contributing to the Diathesis-Stress/Two-Hit model of depression, and is reviewed to provide examples of how this model has been used to investigate the effects of early experience on later neurobiology, physiology, and behavior associated with depression.
Social buffering of stress responses in nonhuman primates: Maternal regulation of the development of emotional regulatory brain circuits
Taking advantage of this naturalistic animal model of adverse maternal caregiving, it is shown that competent maternal care is critical for the development of healthy attachment, social behavior, and emotional and stress regulation, as well of the neural circuits underlying these functions.
arly life adversity during the infant sensitive period for attachment : rogramming of behavioral neurobiology of threat processing and ocial behavior
The interaction between trauma and attachment during a sensitive period in early life is described, which highlights the role of the caregiver’s presence in engagement of attachment brain circuitry and suppressing threat pro-actively.
Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates
The developmental impact of maltreatment on amygdala functional connectivity (FC) longitudinally, from infancy through the juvenile period, may underlie the poor behavioral outcomes associated with this adverse experience of infant maltreatment.


Early adverse experience as a developmental risk factor for later psychopathology: Evidence from rodent and primate models
Increasing evidence supports the view that the interaction of perinatal exposure to adversity with individual genetic liabilities may increase an individual's vulnerability to the expression of
Influences of environmental demand on maternal behavior and infant development
Evidence now suggests that when the mother's survival requirements increase, and her coping capacities are exceeded, both short and long‐term deleterious effects on her developing offspring may emerge, the product of altered neurodevelopment of the serotonergic and noradrenergic systems.
Effects of Early Parenting on Growth and Development in a Small Primate
It is suggested that the quality of parental care influences later growth and behavior in the young marmoset, and the frequency of positive parental behaviors during infancy is correlated with stature when the monkeys reach 10 and 20 wk of age.
Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood.
The findings suggest that hypothalamic-pituitary-adrenal axis and autonomic nervous system hyperreactivity, presumably due to CRF hypersecretion, is a persistent consequence of childhood abuse that may contribute to the diathesis for adulthood psychopathological conditions.
Early experience affects the intergenerational transmission of infant abuse in rhesus monkeys.
  • D. Maestripieri
  • Psychology, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
Results suggest that the intergenerational transmission of infant abuse in rhesus monkeys is the result of early experience and not genetic inheritance, and the extent to which the effects ofEarly experience on the intergeneration transmission of abusive parenting are mediated by social learning or experience-induced physiological alterations remains to be established.