The impact of early adverse care on HPA axis development: Nonhuman primate models

  title={The impact of early adverse care on HPA axis development: Nonhuman primate models},
  author={Mar M. Sanchez},
  journal={Hormones and Behavior},
  • M. Sanchez
  • Published 1 November 2006
  • Psychology, Biology
  • Hormones and Behavior

The Neurobiology of Intervention and Prevention in Early Adversity.

The research on three neurobiological systems relevant to interventions for populations experiencing high levels of early adversity are summarized: the hypothalamic-adrenal-pituitary axis, the prefrontal cortex regions involved in executive functioning, and the system involved in threat detection and response, particularly the amygdala.

Nonhuman primate models of depression: effects of early experience and stress.

The NHP offers an excellent model to research mechanisms contributing to the Diathesis-Stress/Two-Hit model of depression, and is reviewed to provide examples of how this model has been used to investigate the effects of early experience on later neurobiology, physiology, and behavior associated with depression.

Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates

The developmental impact of maltreatment on amygdala functional connectivity (FC) longitudinally, from infancy through the juvenile period, may underlie the poor behavioral outcomes associated with this adverse experience of infant maltreatment.

Models of stress in nonhuman primates and their relevance for human psychopathology and endocrine dysfunction.

It is concluded that studies ofstress in nonhuman primates can model many features of stress exposure in human populations and that such studies can play a valuable role in helping to elucidate the mechanisms underlying the role of stress in human psychopathology and endocrine dysfunction.

Using cross-species comparisons and a neurobiological framework to understand early social deprivation effects on behavioral development

This work explores the impact of early maternal deprivation on neural development and plasticity in three neural systems: hyperactivity/impulsivity, executive function, and hypothalamic–pituitary–adrenal axis functioning across rodent, nonhuman primate, and human studies.



Early adverse experience as a developmental risk factor for later psychopathology: Evidence from rodent and primate models

Increasing evidence supports the view that the interaction of perinatal exposure to adversity with individual genetic liabilities may increase an individual's vulnerability to the expression of

Influences of environmental demand on maternal behavior and infant development

Evidence now suggests that when the mother's survival requirements increase, and her coping capacities are exceeded, both short and long‐term deleterious effects on her developing offspring may emerge, the product of altered neurodevelopment of the serotonergic and noradrenergic systems.

Effects of Early Parenting on Growth and Development in a Small Primate

It is suggested that the quality of parental care influences later growth and behavior in the young marmoset, and the frequency of positive parental behaviors during infancy is correlated with stature when the monkeys reach 10 and 20 wk of age.

Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood.

The findings suggest that hypothalamic-pituitary-adrenal axis and autonomic nervous system hyperreactivity, presumably due to CRF hypersecretion, is a persistent consequence of childhood abuse that may contribute to the diathesis for adulthood psychopathological conditions.

Early experience affects the intergenerational transmission of infant abuse in rhesus monkeys.

  • D. Maestripieri
  • Psychology, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
Results suggest that the intergenerational transmission of infant abuse in rhesus monkeys is the result of early experience and not genetic inheritance, and the extent to which the effects ofEarly experience on the intergeneration transmission of abusive parenting are mediated by social learning or experience-induced physiological alterations remains to be established.

Child abuse and neglect and the brain--a review.

  • D. Glaser
  • Psychology
    Journal of child psychology and psychiatry, and allied disciplines
  • 2000
The importance of early intervention and attention to the chronicity of environmental adversity may indicate the need for permanent alternative caregivers, in order to preserve the development of the most vulnerable children.