The impact of early ADME profiling on drug discovery and development strategy

@inproceedings{Wang2004TheIO,
  title={The impact of early ADME profiling on drug discovery and development strategy},
  author={Jianling Wang and L{\'a}szl{\'o} Urb{\'a}n},
  year={2004}
}
The increased costs in the discovery and development of new drugs, due in part to the high attrition rate of drug candidates in development, has led to a new strategy to introduce early, parallel evaluation of efficacy and biopharmaceutical properties of drug candidates. Investigation of terminated projects revealed that the primary cause for drug failure in the development phase was the poor pharmacokinetic and ADMET (Absorption, Distribution, Metabolism, Discretion and Toxicity) properties… CONTINUE READING

Figures and Tables from this paper.

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies

  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2016
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED