The impact of dyskeratosis congenita mutations on the structure and dynamics of the human telomerase RNA pseudoknot domain.

@article{Yingling2007TheIO,
  title={The impact of dyskeratosis congenita mutations on the structure and dynamics of the human telomerase RNA pseudoknot domain.},
  author={Yaroslava G. Yingling and Bruce A. Shapiro},
  journal={Journal of biomolecular structure & dynamics},
  year={2007},
  volume={24 4},
  pages={303-20}
}
The pseudoknot domain is a functionally crucial part of telomerase RNA and influences the activity and stability of the ribonucleoprotein complex. Autosomal dominant dyskeratosis congenita (DKC) is an inherited disease that is linked to mutations in telomerase RNA and impairs telomerase function. In this paper, we present a computational prediction of the… CONTINUE READING