The impact of drug shortages on children with cancer--the example of mechlorethamine.

@article{Metzger2012TheIO,
  title={The impact of drug shortages on children with cancer--the example of mechlorethamine.},
  author={Monika L. Metzger and Amy L Billett and Michael P. Link},
  journal={The New England journal of medicine},
  year={2012},
  volume={367 26},
  pages={
          2461-3
        }
}
Among the generic drugs in short supply is mechlorethamine, part of a standard regimen for pediatric Hodgkin's lymphoma. The Pediatric Hodgkin Lymphoma Consortium has substituted cyclophosphamide, which is less effective and increases the risk of complications. 

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...

References

SHOWING 1-4 OF 4 REFERENCES

Drug shortages--a critical challenge for the generic-drug market.

  • B. Chabner
  • Medicine, Political Science
    The New England journal of medicine
  • 2011
To address the growing U.S. shortages of critical generic drugs, long-term remedies, both legislative and regulatory, must be considered. Some basic changes in generic-drug law and FDA practices and

Chemotherapy drug shortages in the United States: genesis and potential solutions.

In October 2011, the US Food and Drug Administration announced the end of the cytarabine shortage, but in July 2011, shortages of daunorubicin started, another drug critical to the management of leukemia and the second most important drug used to treat acute myeloid leukemia.

The shortage of essential chemotherapy drugs in the United States.

Some essential oncology drugs are in short supply in the United States, raising concern about safety, cost, and availability of life-saving treatments. The causes are economic: manufacturers don't

motherapy drug shortages in the United States : genesis and potential solutions

  • J Clin Oncol
  • 2012