The impact of drug-induced QT interval prolongation on drug discovery and development

@article{Fermini2003TheIO,
  title={The impact of drug-induced QT interval prolongation on drug discovery and development},
  author={Bernard Fermini and Anthony A Fossa},
  journal={Nature Reviews Drug Discovery},
  year={2003},
  volume={2},
  pages={439-447}
}
During the past decade, a number of non-cardiovascular drugs have had their label revised or have been withdrawn from the market because of unexpected post-marketing reports of sudden cardiac death associated with a prolongation of the QT interval, and an increased propensity to develop a ventricular tachyarrhythmia called Torsades de Pointes. Although a direct link between QT interval prolongation and arrhythmogenesis is still unclear, QT prolongation is now the subject of increased regulatory… 

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