The impact of dropouts on the analysis of dose-finding studies with recurrent event data.

@article{Akacha2010TheIO,
  title={The impact of dropouts on the analysis of dose-finding studies with recurrent event data.},
  author={Mouna Akacha and Norbert Benda},
  journal={Statistics in medicine},
  year={2010},
  volume={29 15},
  pages={1635-46}
}
This work is motivated by dose-finding studies, where the number of events per subject within a specified study period form the primary outcome. The aim of the considered studies is to identify the target dose for which the new drug can be shown to be as effective as a competitor medication. Given a pain-related outcome, we expect a considerable number of patients to drop out before the end of the study period. The impact of missingness on the analysis and models for the missingness process… CONTINUE READING