• Biology, Medicine
  • Published in Nature Reviews Immunology 2012
  • DOI:10.1038/nri3277

The impact of differential antiviral immunity in children and adults

@article{Prendergast2012TheIO,
  title={The impact of differential antiviral immunity in children and adults},
  author={Andrew J Prendergast and Paul Klenerman and Philip Jeremy Renshaw Goulder},
  journal={Nature Reviews Immunology},
  year={2012},
  volume={12},
  pages={636-648}
}
The course of immune maturation has evolved to favour survival at each stage of development in early life. Fetal and neonatal immune adaptations facilitate intrauterine survival and provide early postnatal protection against extracellular pathogens, but they leave infants susceptible to intracellular pathogens such as viruses that are acquired perinatally. This Review focuses on three such pathogens — HIV, hepatitis B virus and cytomegalovirus — and relates the differential impact of these… CONTINUE READING

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