The impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome in humans.

@article{Lipscomb2003TheIO,
  title={The impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome in humans.},
  author={John C. Lipscomb and Linda K. Teuschler and Jeff Swartout and Doug Popken and T. I. Cox and Gregory L Kedderis},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  year={2003},
  volume={23 6},
  pages={1221-38}
}
Risk assessments include assumptions about sensitive subpopulations, such as the fraction of the general population that is sensitive and the extent that biochemical or physiological attributes influence sensitivity. Uncertainty factors (UF) account for both pharmacokinetic (PK) and pharmacodynamic (PD) components, allowing the inclusion of risk-relevant information to replace default assumptions about PK and PD variance (uncertainty). Large numbers of human organ donor samples and recent… CONTINUE READING

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