The impact of cognitive reserve on brain functional connectivity in Alzheimer's disease.

@article{Bozzali2015TheIO,
  title={The impact of cognitive reserve on brain functional connectivity in Alzheimer's disease.},
  author={Marco Bozzali and Claire Dowling and Laura Serra and Barbara Span{\`o} and Mario Torso and Camillo Marra and Diana Castelli and Nicholas G. Dowell and Giacomo Koch and Carlo Caltagirone and Mara Cercignani},
  journal={Journal of Alzheimer's disease : JAD},
  year={2015},
  volume={44 1},
  pages={243-50}
}
One factor believed to impact brain resilience to the pathological damage of Alzheimer's disease (AD) is the so-called "cognitive reserve" (CR). A critical issue that still needs to be fully understood is the mechanism by which environmental enrichment interacts with brain plasticity to determine resilience to AD pathology. Previous work using PET suggests that increased brain connectivity might be at the origin of the compensatory mechanisms implicated in this process. This study aims to… CONTINUE READING