The impact of cellular networks on disease comorbidity

  title={The impact of cellular networks on disease comorbidity},
  author={Juyong Park and Deok-Sun Lee and Nicholas A. Christakis and Albert-L{\'a}szl{\'o} Barab{\'a}si},
  journal={Molecular Systems Biology},
  pages={262 - 262}
The impact of disease-causing defects is often not limited to the products of a mutated gene but, thanks to interactions between the molecular components, may also affect other cellular functions, resulting in potential comorbidity effects. By combining information on cellular interactions, disease-gene associations, and population-level disease patterns extracted from Medicare data, we find statistically significant correlations between the underlying structure of cellular networks and disease… CONTINUE READING
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