The impact of carrier flow rate and infusion set dead-volume on the dynamics of intravenous drug delivery.

@article{Lovich2005TheIO,
  title={The impact of carrier flow rate and infusion set dead-volume on the dynamics of intravenous drug delivery.},
  author={Mark A Lovich and Jason Doles and Robert A. Peterfreund},
  journal={Anesthesia and analgesia},
  year={2005},
  volume={100 4},
  pages={1048-55}
}
The dynamics of IV drug delivery resulting from drug infusions connected to main-line crystalloid carriers can be complex and depend on infusion set dead-volume, drug flow rate, and carrier flow rate. While the concept of dead-volume is intuitive, a lack of appreciation of the interaction with the carrier and drug flow rates can lead to unintended clinical effects resulting from large variations in the delivery rate of potent drugs. We derived mathematical models to quantify these interactions… CONTINUE READING

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