The impact of capecitabine and oxaliplatin in the preoperative multimodality treatment in patients with carcinoma of the rectum: NSABP R-04.

@article{Roh2011TheIO,
  title={The impact of capecitabine and oxaliplatin in the preoperative multimodality treatment in patients with carcinoma of the rectum: NSABP R-04.},
  author={Mark S. Roh and G. A. Yothers and Michael J. O'connell and Robert W. Jr. Beart and Henry C. Pitot and Anthony Frank Shields and David S. Parda and Saima Sharif and Carmen J. Allegra and Nicholas J. Petrelli and Jerome C. Landry and David P. Ryan and Amit Arora and Terry L Evans and Gamini S. Soori and Luis Chu and Reid Landes and Mohammed Mohiuddin and Samia H. Lopa and Norman Wolmark},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 15_suppl},
  pages={3503}
}
3503 Background: The optimal chemotherapy regimen to be given concurrently with preop radiation therapy (RT) in patients with resectable adenocarcinoma of the rectum is unknown. NSABP R-04 compared the efficacy of 4 chemotherapy regimens administered concomitantly with preop RT. METHODS Patients with clinical stage II or III rectal cancer undergoing preop RT (4,500cGy in 25 fractions over 5 wk + boost of 540cGy-1080cGy in 3-6 daily fractions) were randomly assigned to one of the following… CONTINUE READING

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