The impact of blinding on the results of a randomized, placebo‐controlled multiple sclerosis clinical trial

  title={The impact of blinding on the results of a randomized, placebo‐controlled multiple sclerosis clinical trial},
  author={John H. Noseworthy and George Cornell Ebers and Margaret K. Vandervoort and Rochelle Farquhar and Elizabeth Yetisir and Robin Roberts},
  pages={16 - 16}
In the randomized, placebo-controlled, physician-blinded Canadian cooperative trial of cyclophosphamide and plasma exchange, neither active treatment regimens (group I: IV cyclophosphamide and prednisone; group II: weekly plasma exchange, oral cyclophosphamide, and prednisone) were superior to placebo (group III: sham plasma exchange and placebo medications) using the blinded, evaluating neurologists' assessments of disease course (primary analysis). All patients were examined by both a blinded… 

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