The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro

@inproceedings{Koch2010TheIO,
  title={The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro},
  author={Felix Peter Koch and Sareh Said Yekta and Christina Merkel and Thomas Ziebart and Ralf Smeets},
  booktitle={Head & face medicine},
  year={2010}
}
BACKGROUND Bisphosphonates are widely used in the clinical treatment of bone diseases with increased bone resorption. In terms of side effects, they are known to be associated with osteonecrosis of the jaw (BONJ).The objective of this study was to evaluate the effect of bisphosphonates on osteoblast proliferation by cell count and gene expression analysis of cyclin D1 in vitro. Furthermore, the gene expression of the extracellular matrix protein collagen type I was evaluated. Nitrogen… CONTINUE READING
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