The impact of benzodiazepines on occurrence of pneumonia and mortality from pneumonia: a nested case-control and survival analysis in a population-based cohort

@article{Obiora2012TheIO,
  title={The impact of benzodiazepines on occurrence of pneumonia and mortality from pneumonia: a nested case-control and survival analysis in a population-based cohort},
  author={E. Nneji Obiora and Richard B. Hubbard and Robert D. Sanders and Puja Myles},
  journal={Thorax},
  year={2012},
  volume={68},
  pages={163 - 170}
}
Objectives Benzodiazepines have been associated with an increased incidence of infections, and mortality from sepsis, in the critically ill. Here, we determined the effect of community use of benzodiazepines on the occurrence of, and mortality following, pneumonia. Methods A nested case-control study using 29 697 controls and 4964 cases of community-acquired pneumonia (CAP) from The Health Improvement Network, a UK primary care patient database (2001–2002), investigated the association between… 
The impact of benzodiazepines on occurrence of pneumonia and mortality from pneumonia: a nested case-control and survival analysis in a population-based cohort
TLDR
The National Health Insurance Database of 22 million (2002) population is used in order to investigate the association of benzodiazepines and community-acquired pneumonia (CAP).
Benzodiazepines and risk of pneumonia in schizophrenia: a nationwide case–control study
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Benzodiazepines had a dose-dependent relationship with pneumonia in patients with schizophrenia, and the current use (within 30 days) of midazolam led to the highest pneumonia risk, while nearly all the benzodiazepine under current use had a doses-dependent effect on pneumonia risk.
Benzodiazepine Use and Risk of Community-Acquired Pneumonia in a Population-Based Cohort Study From North-Eastern Spain:
Background:Benzodiazepine (Bz) exposure has been identified as a risk factor of community-acquired pneumonia (CAP) in some observational studies, but this remains controversial. This study was
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TLDR
Treatment with benzodiazepines as a concomitant medication had no independent impact on stroke outcome and pneumonia rates among patients registered in a trials archive were assessed.
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TLDR
BZRA use may be associated with an increased mortality among patients hospitalised for COVID-19, suggesting the potential benefit of decreasing dose or tapering off gradually these medications when possible, except for diazepam, which may beassociated with a reduced mortality compared with any other BZRA treatment.
Benzodiazepine use and risk of mortality among patients with schizophrenia: a retrospective longitudinal study.
TLDR
Benzodiazepine use is associated with increased mortality risk in patients with schizophrenia after adjusting for a wide range of potential confounders, and physicians should exercise caution in prescribing benzodiazepines to schizophrenic patients.
Association between benzodiazepine use and risks of chronic-onset poststroke pneumonia: a population-based cohort study
TLDR
BZD use is associated with an increased risk of chronic-onset poststroke pneumonia and all BZD user subgroups were associated with a higher risk of pneumonia.
The use of benzodiazepines could be a protective factor for community-acquired pneumonia (CAP) in ≤60-year-old subjects
TLDR
New data are presented from a previously published population-based case-control study carried out in a sample of 2662 subjects (1336 CAP patients and 1326 controls) to contribute to this unsolved question of the effect of BZs in patients with CAP.
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